Why is it so important to know about the ApoE gene?

What is the ApoE Gene?

The ApoE gene gives your body instructions for producing the lipid-binding protein called Apolipoprotein E. This production, mostly, occurs in the liver as well as glial cells that help your neurons. ApoE molecules’ job is indispensable: they support the transportation of cholesterol and fats via the water-based highway of the bloodstream and cerebrospinal fluid.

Its most critical roles include:

  1. Moving fats and cholesterol through the blood and cerebrospinal fluid [1]
  2. Protecting neurons and the brain by bringing regenerative building blocks–fats and cholesterol–to damaged areas [2]
  3. Protecting against infections by controlling immune function [3]
  4. Critical in the Reduction of beta amyloid and neurofibrillary (tau) tangles, which have been found in the brains of Alzheimer’s patients [4, 5]
  5. Reducing oxidative stress [6]

 

There are three common versions of the ApoE gene: ApoE-𝛆2, ApoE-𝛆3, and ApoE-𝛆4. The most common one in the population is ApoE-𝛆3, followed by ApoE-𝛆4 and ApoE-𝛆2.

The different versions are the result of of variants which change the amino acids in the ApoE protein, thereby, altering its molecular properties.

Significant Clinical Research supports that ApoE-𝛆4 is a known cause of Alzheimer’s disease and mild cognitive impairment, as well as a major risk factor for cardiovascular disease. This variant both increases the odds and reduces the age of onset of Alzheimer’s. Conversely, ApoE-𝛆2 is protective against Alzheimer’s disease and is one of the variants most associated with longevity.

Additionally, the diseases mentioned above are strongly associated with diet and have a strong non-genetic component. Genes direct the traffic while diet, lifestyle, and overall health run the engines of the cars.

Set an appointment to find out how we can test to see which version of this gene you are carrying.  This could be a critical determinant in your Lifestyle Protocol.

References:

  1. Holtzman, D. M. et al. Cold Spring Harb. Perspect. Med. 2, a006312 (2012)
  2. Strittmatter, W. J. et al. Proc. Natl. Acad. Sci. U. S. A. 91, 11183–6 (1994)
  3. Vitek, M. P. et al. Neurobiol. Aging 30, 1350–60 (2009)
  4. Ulrich, J. D. et al. J. Exp. Med. 215, 1047–1058 (2018)
  5. Strittmatter, W. J. et al. Proc. Natl. Acad. Sci. U. S. A. 91, 11183–6 (1994)
  6. Miyata, M. et al. Nat. Genet. 14, 55–61 (1996)
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Dr. Deepti Sadhwani

Internal & Bariatric Medicine

Dr. Deepti is respected around the world for her work as a nutritional and weight management expert. She specializes in disease prevention and chronic disease reversal.

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Dr. Harish Sadhwani

Internal & Bariatric Medicine

Dr. Harish has an innate knowledge to accurately diagnose all diseases of the body, determine the appropriate treatments, as well as the necessary steps that one can take in preventing most diseases and their symptoms.

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Mark Hasenauer, P.A.

Internal & Bariatric Medicine

Mark was born in Fort Lauderdale and raised in Sebastian, Florida. He attended Florida Institute of Technology for his undergraduate education.

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Joel Shields, B.D.O / H.N.C

Joel Shields has a burning desire and passion to help others live a more fulfilling and healthy life and working alongside Dr. Deepti and the rest of the staff at QHC Wellness Institute has allowed him to do just that.

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Nicole Bladin, APRN

Nicole is a Nurse Practitioner certified through the American Association of Nurse Practitioners (AANP). Nicole has been working in the medical field, starting as a Certified Nurse’s Assistant, since the age of 18.

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