Gut Barrier

The gut is a hollow tube that passes from the mouth to the anus. Anything that is swallowed in the mouth and isn’t digested will be excreted out the other end. In fact, this is one of the most important functions of the gut: to prevent harmful foreign substances from entering the body.

Leaky Gut Syndrome is a condition when the intestinal barrier becomes permeable and large protein molecules escape into the bloodstream. Since these proteins don’t belong outside of the gut, the body reacts by triggering an immune response and attacks them. Research indicates these attacks are an important consideration in the development of autoimmune diseases like Hashimoto’s and other diseases like type 1 diabetes. There is growing evidence that increased intestinal permeability plays a pathogenic role in various autoimmune diseases including [celiac disease] and [type 1 diabetes]. Therefore, we hypothesize that besides genetic and environmental factors, loss of intestinal barrier function is necessary to develop autoimmunity.

The phrase itself, “leaky gut”, used to be confined to the outer fringes of medicine With Conventional researchers and doctors originally scoffing at the idea that a leaky gut contributes to autoimmune problems. They have since changed their tunes. It has been repeatedly demonstrated in several well-designed studies that the integrity of the intestinal barrier is a critical factor in autoimmune disease.

This new theory maintains that the intestinal barrier is the most important determinant whether we tolerate or react to toxic environmental substances we ingest. The breach of the intestinal barrier (which is only possible with a “leaky gut”) by food toxins (gluten) and chemicals (like arsenic or BPA) causes an immune response which affects not only the gut itself but also other organs and tissues including the skeletal system, the pancreas, the kidney, the liver, and the brain.


The result is that Leaky gut and bad gut flora are common because of the modern and often called “Western Lifestyle”. These conditions often occur simultaneously: If you have a leaky gut, you probably have bad gut flora and vice versa. And when your gut flora and gut barrier are impaired, you will be inflamed because your body is in battle mode against the intruding food and/or chemical toxins your gut barrier was supposed to block.

This systemic inflammatory response then leads to the development of autoimmunity. And while leaky gut and bad gut flora may manifest as digestive trouble, in many people it does not. Rather, it manifests as cross-system problems such as heart failure, depression, and brain fog; skin conditions like eczema and psoriasis; metabolic problems like obesity and diabetes; and allergies, asthma, and other autoimmune diseases.

Before you can address these conditions, you must, first, rebuild healthy gut flora and restore the integrity of your intestinal barrier. This holds true especially if you have developed any kind of autoimmune disease, whether you’re experiencing digestive issues or not.


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By Dr. Deepti

Dr. Deepti Sadhwani

Internal & Bariatric Medicine

Dr. Deepti is respected around the world for her work as a nutritional and weight management expert. She specializes in disease prevention and chronic disease reversal.

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Dr. Harish Sadhwani

Internal & Bariatric Medicine

Dr. Harish has an innate knowledge to accurately diagnose all diseases of the body, determine the appropriate treatments, as well as the necessary steps that one can take in preventing most diseases and their symptoms.

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Mark Hasenauer, P.A.

Internal & Bariatric Medicine

Mark was born in Fort Lauderdale and raised in Sebastian, Florida. He attended Florida Institute of Technology for his undergraduate education.

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Joel Shields, B.D.O / H.N.C

Joel Shields has a burning desire and passion to help others live a more fulfilling and healthy life and working alongside Dr. Deepti and the rest of the staff at QHC Wellness Institute has allowed him to do just that.

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Nicole Bladin, APRN

Nicole is a Nurse Practitioner certified through the American Association of Nurse Practitioners (AANP). Nicole has been working in the medical field, starting as a Certified Nurse’s Assistant, since the age of 18.

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